Aspirin and fracture risk: A systematic review and exploratory meta-analysis of observational studies

AL Barker; SE Soh; KM Sanders; J Pasco; S Khosla; PR Ebeling; SA Ward; G Peeters; J Talevski; RG Cumming; E Seeman; JJ McNeil

Journal article

Aspirin and fracture risk: A systematic review and exploratory meta-analysis of observational studies

AL Barker, SE Soh, KM Sanders, J Pasco, S Khosla, PR Ebeling, SA Ward, G Peeters, J Talevski, RG Cumming, E Seeman, JJ McNeil

BMJ Open | BMJ PUBLISHING GROUP | Published : 2020

DOI: 10.1136/bmjopen-2018-026876

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Abstract

Objectives This review provides insights into the potential for aspirin to preserve bone mineral density (BMD) and reduce fracture risk, building knowledge of the risk-benefit profile of aspirin. Methods We conducted a systematic review and exploratory meta-analysis of observational studies. Electronic searches of MEDLINE and Embase, and a manual search of bibliographies was undertaken for studies published to 28 March 2018. Studies were included if: participants were men or women aged ≥18 years; the exposure of interest was aspirin; and relative risks, ORs and 95% CIs for the risk of fracture or difference (percentage or absolute) in BMD (measured by dual energy X-ray absorptiometry) betwee..

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University of Melbourne Researchers

Sze-Ee Soh Author

Kerrie Sanders Author

Jason Talevski Author

Ego Seeman Author

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by an Australian National Health and Medical Research Council (NHMRC) Project Grant (project number: APP1067242). ALB was supported by a NHMRC Career Development Fellowship (1067236). JT was supported by a National Health and Medical Research Council (NHMRC) Postgraduate Scholarship (1151089).